Design and Synthesis of
O-(4-bromo)-phenyl-N-(9’-acridinyl)-hydroxylamines
Abstract
Being one of the top 3 causes of death in the world, cancer is proving to need better and more effective treatments. This has made it necessary for research to be done on anti-tumor drugs. 9’-aminoacridine has been found to be anti-tumor. The 9’-aminoacridine is a DNA intercalator. The DNA intercalator binds to DNA and interrupts the cell reproduction cycle. The goal of this is to produce a bromine substituent derivative of O-phenyl-N-(9’-acridinyl)-hydroxylamine. Since the bromine is a deactivating element, the drug is hypothesised to attach a little bit stronger than the base drug.